Maria C Castells, MD, PhD
Not currently accepting new patients
4.896774 average rating from 62 patient reviews
Specialties
Affiliation
Mass General Brigham
Provider Locations
- Chestnut Hill, MA
- Boston, MA
Mariana Castells, MD, PhD is a clinician, researcher and teacher at Brigham and Women's Hospital and Dana Farber Cancer Institute. She is the Director of the Drug Hypersensitivity and Drug Desensitization Center and of the Mastocytosis Center and has served as the Allergy and Clinical Immunology Training Program Director for over 20 years.
Dr Castells has spearheaded the evaluation and understanding of anaphylaxis and drug hypersensitivity and has developed desensitization protocols which are used as standards around the world, treating thousands of patients with cancer and chronic inflammatory diseases, maintaining these patients on first line therapy. She sees and treat patients with drug allergy, anaphylaxis, mast cell activation disorders, urticaria, immune deficiencies, regular food and environmental allergies and asthma.
Her research has uncovered mast cell inhibitory mechanisms which are pertinent to desensitization and her laboratory is actively pursuing pharmacological candidates to improve the safety and efficacy of desensitizations. She has pioneered the diagnosis and treatment of mast cell activation disorders and mastocytosis and is the PI of clinical trials with Tyrosine Kinase Inhibitors.
Dr Castells served on the Board of Directors of The American Academy of Allergy, Asthma & Immunology (AAAAI), and is now the research chair of the AAAAI Foundation. She is on the Board of Directors for the ABAI, has been at the Editorial Board of the Journal of Allergy and Clinical Immunology (JACI), the JACI In Practice and Annals of Allergy, Asthma and Immunology. She has served at the council of the Collegium Internationale Allergologicum and directs the International Drug Desensitization Meeting (DDIM) in Barcelona, Spain, yearly.
Education & Training
- Residency: Kansas University Medical Center, Allergy & Immunology, 1990
- Fellowship: Medical College of Virginia, Allergy & Immunology, 1988
- Internship: Kansas University Medical Center, 1980
- Medical Education: Universidat Autonoma de Barcelona, Spain, 1979
Board Certifications
- Allergy and Immunology, American Board of Allergy and Immunology
Languages Spoken
- Spanish
- Italian
- French
- English
Age Group Treated
- Adults
Patient Feedback
4.896774 average rating from 62 reviews
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Dr Castells is the absolute best in the field and it is incredible to be her patient.
2026-07-05
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I am very lucky to have Dr CASTELLS as my doctor She is very knowledgeable about my mast cell condition and hhas helped me manage this situstion
2026-07-04
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I think this provider is excellent and I think she deserves everything she needs to expand her department, continue more research and see more patients or train more people under her. I think she's wonderful. Thank you.
2026-07-03
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She is simply the best. Attentive, respectful from leader in this field.
2026-07-02
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Dr. Castells is the most wonderful blend of scientist, teacher, and practitioner. She provides care and attention to her patients in an unparalleled fashion. I am so appreciative to have her as my doctor.
2026-06-27
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Dr. Castells was worth the wait. I had a consultation scheduled with her regarding mcas and she was absolutely wonderful! She took the time to go through my history and symptoms thoroughly, she showed compassion and care, she explained everything in an easy to understand manner, and she answered all of my questions. We ordered labs, made a plan of care, and she sent me on my way feeling heard, seen, and helped me when other providers looked at me puzzled, Dr Castells gave me help. Thank you Dr. Castells!!!
2026-06-27
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Dr Castells has been my Systemic Mast Cell physician for many years. Without her world class knowledge I would never be in the health I am today. [redacted] When I was sent to Immunology to Doctors [redacted] and the mighty Dr. Maria Castells my life began to change. I am grateful for their intelligence, training, and skill. Equally for the medical advancements.
2026-06-13
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Dr. Castells is truly a God send. She is the smartest provider I have ever been in the presence of, and makes me feel so confident that my health will remain strong even with my Mastocytosis diagnosis. I trust her, her opinions/facts, and her team 1000% which is so rare. She also never makes me feel rushed, even when she had a flight to take the next day to go speak in Lebanon at a mastocytosis convention; she still took ample time to discuss everything with me, answer all of my mom and I's questions, and talk about my pregnancy as well. I appreciate her dedication to her studies, her research, and her patients in ways I cannot put into words. I am so thankful and feel so lucky to be in her care. She truly is the definition of an outstanding provider who genuinely loves what she does and who she does it for.
2026-06-13
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Thank you and I am very grateful.
2026-06-06
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This provider has provided us with life changing care! We were lost before we found her. We can't begin to put into words how much her care has changed our son's life!
2026-05-24
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Dr. Castells has been my main physician for managing my mast cell activation condition. She has been the one doctor who clearly understands this medical issue, and she has guided me through surgeries and illness.
2026-05-23
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Dr Castells is an amazing world expert on Mast cell issues. Most providers in my home area are not familiar with these issues so it is very helpful to be able to come here.
2026-05-16
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Dr. Castells is an extremely competent and knowledgeable physician. What sets her apart is her true vocation to care for her patients that have a very complex medical condition.
2026-05-03
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Very professional, very friendly, very honest, and I had always been there for questions. I am very lucky to have an I am very lucky to have a doctor like her and explanations and treatment choices. impressive physician.
2026-05-02
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Thank you Dr. Maria Castells
2026-04-29
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Very thorough and caring.
2026-04-03
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Everyone was so nice & helpful. [redacted] Dr Castells was so incredibly nice and provided me with a lot of information about my bone marrow biopsy [redacted], and my many genetical syndromes and 2 autoimmune disorders. Thankfully she was able to advise me on medications for my upcoming mastectomy and talk to me about a few particulars of importance to managing my stress levels (stress makes my mast cells degranulate and there's much sickness with just that alone). So thankful to have Dr Castells as my new allergist
2026-03-11
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She was excellent and the length of the appointment was appropriate.
2026-03-11
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Dr. Castells has always been excellent and continues to do so. I've been seeing her since 2014. I'm always learning. I'm always told everything I need to be told. And if anything, the only issue is me remembering everything.
2026-02-27
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Very pleasant and made me feel comfortable since I've been pushed aside by others in the past she really listened
2026-02-24
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My provider, Maria Castells, is very capable, professionally respected, and I am pleased and privileged to be able to see her with my condition.
2026-02-27
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Always treated with respect!
2026-01-29
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My experience was amazing. The doctor was extremely knowledgeable and kind. I left my visit fully informed and now have a very positive outlook going forward knowing the care I will receive.
2025-12-09
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Dr Castells was absolutely amazing. She explained my condition to my husband & I thoroughly in easy to understand language. Dr Castells was so kind compassionate & took the time to answer all of our questions & concerns & was so knowledgeable & insightful. I am so grateful for the opportunity to have been seen by Dr Castells for my condition.
2025-11-22
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I pray that I will be an appropriate patient for a new medication that was proposed for my health issue. It has been difficult for me for several years. My health has certainly been improved upon through my time with Dr Castells and I am most hopeful. So much to gain if possible.
2025-11-22
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Dr Castells is the best of the best.She is absolutely one of a kind ,her knowledge,expertise,research,and kindness are unsurpassed.
2025-11-21
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Dr. Castells is my main physician, and I feel utterly confident in her ability to help me with my health issues.
2025-10-31
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I am so grateful to have Dr Castells as my physician provider.
2025-10-19
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The Best!
2025-09-10
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EXCELLENT DR, VERY KNOWLEDGABLE, COMPASSIONATE AND KIND
2025-09-08
Accepted Insurance
- Tufts Medicare Preferred
- Wellpoint
- Humana
- Blue Cross Blue Shield Medicare
- Medicaid NH
- Medicaid ME
- Beech Street
- Multiplan
- Senior Whole Health
- United Health Care
- WellSense
- Medicaid VT
- Mass General Brigham Health Plan
- TriCare
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- Tufts Health Plan
- Medicaid CT
- Fallon Health
- Medicare
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