Samuel J Klempner, MD

Samuel J Klempner, MD

Not currently accepting new patients

4.966667 average rating from 108 patient reviews

Specialties

Affiliation

Mass General Brigham

Provider Locations

  • Boston, MA

Dr. Klempner completed his residency in internal medicine at Brigham and Women’s Hospital/Harvard Medical School, followed by a combined hematology-oncology fellowship at Beth Israel Deaconess Medical Center/Harvard Medical School. While at Harvard Dr. Klempner studied the mechanisms of resistance to targeted therapies in tumor cells in the lab of Dr. Lewis Cantley, PhD. Dr. Klempner is board certified in medical oncology, hematology, and internal medicine, and belongs to several oncology research societies including the American Society of Clinical Oncology (ASCO), European Society of Medical Oncology (ESMO), the American Association for Cancer Research (AACR). His work has been published in multiple journals including Journal of Clinical Oncology (JCO), Cancer Discovery, Lancet Oncology, JAMA Oncology, Annals of Oncology and others. He is an active member of the ASCO TAPUR trial molecular tumor board and serves on the editorial board of JCO Precision oncology.

As a member of the gastrointestinal cancer group at MGH Dr. Klempner works in a multidisciplinary team to optimize and individualize treatment using molecular characterization across all stages of GI cancers. He conducts clinical trials and translational research with new targeted agents and immune therapies, and is active in the gastroesophageal cancer community where he serves on the advisory board of Debbie's Dream Foundation and Hope for Stomach Cancer. He has received several awards for his care of patients with GI cancers. Originally from Wayland, MA he is an avid Boston sports fan.

Education & Training

  • Fellowship: Beth Israel Deaconess Hospital, Hematology & Oncology, 2013
  • Residency: Brigham and Women's Hospital, Internal Medicine, 2010
  • Medical Education: University of Massachusetts Medical School, 2007

Board Certifications

  • Medical Oncology, American Board of Internal Medicine

Languages Spoken

  • Spanish
  • English

Age Group Treated

  • Adults

Patient Feedback

4.966667 average rating from 108 reviews

  • I look forward to meeting with him in the near future .

    2026-07-02

  • I appreciate being seen. We had a great discussion with MD and his team. Everyone was informative, helpful, honest and professional.

    2026-07-01

  • The Doctor is a true professional, with a great bedside manner, and very knowledgeable.

    2026-06-24

  • Excellent, top notch. Knowledgeable and caring

    2026-06-11

  • Very satisfied with the doctor and his staff.

    2026-05-25

  • Dr. Klempner and his staff are the best!

    2026-05-23

  • He is an awesome very well educated oncologist helped me so much

    2026-05-19

  • I am always happy to be seen by this provider. every thing is good to get health care by this provider

    2026-05-08

  • He's the best doctor, always very caring and considerate of my needs and what I'm going through, my experiences, and he's always very thoughtful, remembers everything, and makes sure that whatever is happening is what I feel comfortable with. So he always tries to accommodate what is best for me.

    2026-04-24

  • exceeded expectations

    2026-04-21

  • Provided a clear discussion about the tests that I requested to have done. It had been two years since my last preventative tests.

    2026-04-22

  • Excellent doctor took his time with us explaining everything.

    2026-04-20

  • Dr. Samuel Klempner and his team are excellent. [redacted]

    2026-04-01

  • I'm very appreciative of Dr. Klempner and all providers I was able to see. It is already a dramatic increase in the quality of care I'm used to receiving. I'm looking forward to receiving as much of my care as possible at Boston MGH and its trusted network. Thank you all, [redacted]

    2026-03-29

  • This provider is excellent about providing all the pertinent information needed for continued improvement....he is extremely knowledgeable and takes time to thoroughly answer all questions and he offers ideas and suggestions for my success with my medical issues.i am very lucky to have such a kind, thoughtful and encouraging medical professional.

    2026-03-26

  • A team the best that I ever seen!

    2026-03-24

  • Dr. Klempner has been nothing short of amazing. He listens and has my best interest in mind.

    2026-03-24

  • The doc was very informative explaining everything. Was also very friendly and listened to us and answered our questions

    2026-03-23

  • Very friendly and easy to talk with. Explained in detail what I was facing.

    2026-03-23

  • Excellent

    2026-03-03

  • Excellent care by everyone involved

    2026-02-26

  • mostly fine

    2026-02-24

  • Very good.

    2026-02-26

  • Dr. Klempner is one of the best doctors I've had in my [redacted] years (and I've seen a lot of doctors!). I know he has an enormous case load, but he treats me like I'm the only one, he's focused, direct, and kind. I know I'm in the very best hands with his care! (My literally life depends on him). Can't say enough positives about him and MGH!

    2026-02-20

  • I am fortunate to have Dr. Klempner and my entire oncology team at MGH. The best!

    2026-02-17

  • Dr. Klempner and his team went over and above to explain in detail what we, my advocate and myself were to expect through all the upcoming cycles, as well as the processes from start to finish. He/they did and especially great job addressing our concerns about the sensitive areas of the treatments as well as broke down the complicated medical jargon and complicated process of drug administration. Dr. Klempner reassured us, made us feel informed and comfortable!

    2026-02-17

  • My first 4 years of cancer treatment was in NJ. My last year was in the care of Dr. Klempner due to our move to Mass. I was impressed with Dr. Klempner's professional manner, his wonderful communication skills and his genuine concern for my well-being.

    2026-02-16

  • The Dr listened patiently to my concerns & gave suggestions regarding my questions.

    2026-02-27

  • Dr. Klempner was extremely professional and walked into the appointment with past knowledge of her medical history. He explained everything thoroughly and in a way that is easy to understand. It was super helpful that he walked us through my mom's recent CT scan and the options she has based on her type of cancer. I only wish we were located in Boston to receive primary care for her.

    2026-02-26

  • Dr Sam Klempner is an outstanding oncologist. He is extremely thorough and explains the phases of my cancer and options available. I am so grateful for is medical advice as well as the support through this process. I'm fortunate to call him my doctor.

    2026-01-21

  • The doctor was professional and caring.

    2025-12-25

  • The best I've ever experienced in terms of familiarity with my case, expertise in his field, clear communication, and empathy.

    2025-12-24

  • I have nothing but the highest praise for Dr.Klempner and his team I have received nothing less than exceptional care from them.

    2025-12-15

  • Dr Klempner is the absolute best oncologist!!!

    2025-12-15

  • I have been seeing Sam for almost 2 years. There aren't enough superlatives to describe him. He is, no doubt, one of the finest Doctors I have ever dealt with in my [redacted] years on this planet!

    2025-12-09

  • Dr Klempner has always been available to me when and if I have concerns regarding my treatment.

    2025-11-26

  • Dr. Klempner is the best in every way! Amazing dedication to his field of expertise!

    2025-11-21

  • Excellent

    2025-11-12

  • Knowledgeable and took the time to explain and listen.

    2025-11-02

  • It was a hood experience, no complaints.

    2025-10-19

  • He completely broke my options down in an easily understandable way. He had an incredibly kind and down to earth manner during our visit. I look forward to being under his care for this cancer journey

    2025-10-19

  • Sam Klempner is outstanding. He explained things to us in an exceptional way and this made me feel like the providers at MGH oncology are determined to help me and their other patients. He has a calming presence and this made me feel safe. Truly, I cannot say enough positive things about him.

    2025-10-19

  • I am pleased he will be taking care of me.

    2025-10-15

  • Dr. Klempner has great technical and coordination skills. His office communicates very well with my other MGH caregivers and coordinates his treatment of me with others on my cancer treatment team.

    2025-10-09

  • I've been seeing Dr. Klintner for almost five years. He actually saved my life. We get along real well. He's very thorough in his explanation of his treatments, and he's very responsible. He's very accurate, and he's very, He's a heartwarming person. He's easy to talk to, easy to get along with, and he's an excellent doctor. He's probably one of the better doctors at Mass General Hospital. I appreciate everything he's done for me. That's all I have to say. Thank you.

    2025-09-21

  • He was AWESOME! Kind, professional, compassionate!

    2025-09-04

  • Yes, Dr. Klempner was amazing. He spent a good hour with us going through all kinds of information and answering any question we had. And we did not get that from our last provider at Sloan. He was just amazing. And I'm thankful that we were sent to him.

    2025-08-22

Accepted Insurance

  • Medicaid VT
  • Tufts Medicare Preferred
  • Wellpoint
  • Aetna
  • Harvard Pilgrim Health Care
  • Medicaid CT
  • MassHealth
  • TriCare
  • Fallon Health
  • Beech Street
  • United Health Care
  • Blue Cross Blue Shield Medicare
  • Blue Cross Blue Shield - Indemnity
  • Tufts Health Plan
  • Coventry
  • Mass General Brigham Health Plan
  • Multiplan
  • Humana
  • Medicaid NH
  • Medicaid ME
  • WellSense NH
  • Medicare ACO
  • Commonwealth Care Alliance
  • Blue Cross Blue Shield
  • Senior Whole Health
  • Cigna
  • Medicare
  • WellSense
  • Medicaid RI
  • Maine Community Health Options