Leon Pappas, MD, PhD, MSC

Not currently accepting new patients

4.725217 average rating from 115 patient reviews

Specialties

Affiliation

Mass General Brigham

Provider Locations

  • Boston, MA

Dr. Pappas is a Medical Oncologist at the Massachusetts General Hospital and Instructor in Medicine at Harvard Medical School. He completed an Internal Medicine Residency at the Massachusetts General Hospital and a Fellowship in Medical Oncology at the Dana-Farber Cancer Institute, Massachusetts General Hospital and Brigham and Women’s Hospital. He holds an MSc in Immunology from the University of Oxford and a PhD in Immunology from the ETH Zurich. He is board certified in Internal Medicine and belongs to several oncology research societies, including the American Society of Clinical Oncology (ASCO).

Dr. Pappas specializes in the treatment of Gastrointestinal cancers, as well as in Developmental Therapeutics. As a medical oncologist in the multidisciplinary Gastrointestinal Oncology group at MGH, he collaborates with providers across multiple specialties to tailor and optimize treatment plans for patients with all stages of cancer. As a member of the Termeer Center for Developmental Therapeutics, he offers patients access to some of the most cutting-edge treatments available in Oncology, with a personalized approach using molecular and genomic tumor profiling to guide therapeutic decision-making. His research focuses on the study of Colorectal Cancer, and he is supported by an ASCO Young Investigator Award. He is passionate about increasing and improving the therapeutic options available to patients, and designs clinical trials with novel targeted therapies and immune therapies.

Education & Training

  • Fellowship: Brigham and Women's Hospital, Medical Oncology, 2024
  • Fellowship: Dana Farber Cancer Institute*, Medical Oncology, 2024
  • Residency: Massachusetts General Hospital, Internal Medicine, 2021
  • Medical Education: Boston University, 2018

Board Certifications

  • Medical Oncology, American Board of Internal Medicine

Languages Spoken

  • English

Age Group Treated

  • Adults

Patient Feedback

4.725217 average rating from 115 reviews

  • Dr. Pappas answered thoroughly and thoughtfully all of my questions. He was well prepared and extremely helpful. I feel very fortunate to be under his care.

    2026-06-04

  • Extremely competent clinition.

    2026-05-22

  • He is very knowledgeable and very friendly to new patients.

    2026-05-17

  • I am just starting with him but everything was positive about his input.

    2026-05-17

  • This was my first meeting with Dr. Pappas. He was thorough and listened to my needs. I've been added to there oncology team for follow up studies. So he was very helpful.

    2026-05-13

  • It was good

    2026-05-11

  • This was my first visit with Dr. Pappas, as I just moved from [redacted]. He was very helpful and well read o my charts. He is very knowledgable and explaind things clearly.

    2026-05-10

  • Very professional and always looking out for my best medical care.

    2026-05-02

  • Very knowledgeable and considerate. Very informative.

    2026-04-30

  • He is an excellent doctor.

    2026-04-30

  • I am well cared for by these providers

    2026-04-24

  • This provider obviously knows his stuff but needs guidance on how to explain things to a patient who's intelligent but does not work in his field.

    2026-04-13

  • Dr. Pappas explained well my situation concerning my cancer cancer care

    2026-04-12

  • I feel safe and trust that Dr. Pappas is always looking out for what is best for my health.

    2026-04-04

  • The care provider himself was wonderful. With each successive visit, becoming familiar with the other, and style, this provider better than matched my style, and provided what I both needed and wanted.

    2026-03-28

  • Dr. Pappas was very knowledgeable and easy to understand. He was very thorough in answering all our questions. We look forward to meeting him in person.

    2026-03-26

  • Dr Pappas looked very efficient, very well qualified and experienced

    2026-03-15

  • Attentive, thoughtful, listened well, knowledgeable

    2026-03-14

  • I felt very welcome. I felt confident. [redacted] Everybody was nice, kind, polite. Every answer was questioned the right way, and I understood every answer from the doctor and the nurses. Love going there. Love my team at Mass General Hospital with Dr. Pappas, the whole team.

    2026-02-13

  • MGH has been incredible through my treatment and follow ups

    2026-02-02

  • Dr Pappas was clear with the information available to him regarding my care

    2026-01-28

  • He had reviewed my medical records prior to seeing me and was aware of my scan results. He listened carefully and answered my questions thoroughly. He provided possible options for future care. He was kind and respectful, and gave me all the time that I needed.

    2026-01-11

  • Dr. Pappas was excellent in explaining everything to me and I feel totally confident that I'm in great hands.

    2026-01-12

  • Great care, responds quickly to text questions. Listens to my concerns.

    2025-12-29

  • Dr. Pappas and his staff were excellent knowledgeable and professional. [redacted]

    2025-12-29

  • Part of continuing care as part of my cancer care and recovery.

    2025-12-24

  • I was glad that Dr. Pappas made it a priority to have a telehealth visit since he was unable to see me in person during my visit to Mass General. I am sure Dr. Pappas has my best interest in his heart and he will make an ernest attempt to find me a slot in his clinical trials. I trust him.

    2025-12-25

  • Very smart. Spoke at a high level at times.

    2025-12-20

  • Dr. Pappas was most encouraging.

    2025-11-27

  • Everyone I encounter is very caring and , knowledgeable

    2025-11-22

  • Very professional

    2025-11-22

  • Very warm caring person.

    2025-11-08

  • Seems very knowledgeable and helpful.

    2025-10-10

  • A very pleasant and informative visit

    2025-10-06

  • very professional and compassionate - extremely knowledgeable about his specialty

    2025-10-04

  • I have the highest respect for Dr. Pappas. He's a wonderful clinician and wonderful bedside manner.

    2025-10-02

  • Excellent service by this care provider. Would definitely recommend him. Thank you.

    2025-09-29

  • Very knowledgeable and concerned with my health challenges.

    2025-09-22

  • I expected more detailed info regarding available trials in the Boston area not just MGH.

    2025-09-20

  • Very professional and caring.

    2025-09-19

  • The doctor was good. The nurses were good. I had a good response. I didn't wait too long. Very happy with it.

    2025-09-04

Accepted Insurance

  • Medicaid CT
  • Tufts Medicare Preferred
  • Multiplan
  • Tricare
  • Maine Community Health Options
  • Harvard Pilgrim Health Care
  • Medicare ACO
  • Aetna
  • Mass General Brigham Health Plan
  • Beech Street
  • Medicare
  • WellSense
  • Humana
  • Commonwealth Care Alliance
  • Fallon Health
  • Wellpoint
  • Blue Cross Blue Shield
  • Coventry
  • Blue Cross Blue Shield Medicare
  • Tufts Health Plan
  • Cigna
  • Medicaid RI
  • MassHealth
  • United Health Care
  • Senior Whole Health