John H Stone, MD, MPH
Not currently accepting new patients
4.921569 average rating from 102 patient reviews
Specialties
Affiliation
Mass General Brigham
Provider Locations
- Boston, MA
- Waltham, MA
Dr. Stone’s work has focused on systemic vasculitides such as giant cell arteritis and ANCA-associated vasculitis, on IgG4-related disease (IgG4-RD), and on glucocorticoid toxicity.
He attended Harvard Medical School and trained in internal medicine at Johns Hopkins. He performed his rheumatology fellowship at the University of California-San Francisco and then returned to Hopkins, where he co-founded The Johns Hopkins Vasculitis Center in 1997. In 2008, he became the Director of Clinical Rheumatology at the Massachusetts General Hospital (MGH).
His work has led to a number of major, practice-changing clinical trials:
- The WGET trial (Etanercept in granulomatosis with polyangiitis)
- The RAVE trial (Rituximab in ANCA-associated vasculitis)
- The GiACTA trial (Tocilizumab in giant cell arteritis)
- The BACC Bay trial (Tocilizumab for the prevention of respiratory failure in COVID)
- The MITIGATE trial (Inebilizumab in IgG4-RD)
- The INDIGO trial (Obexelimab in IgG4-RD)
- The REPLENISH trial (Secukinumab in polymyalgia rheumatica)
The IgG4-RD group at MGH has identified several new disease associations with IgG4-RD, including lymphoplasmacytic thoracic aortitis, eosinophilic angiocentric fibrosis, and Riedel’s thyroiditis. They also made the novel observation that B cell depletion with rituximab leads to swift, targeted declines in serum IgG4 concentrations and that this treatment is associated with dramatic clinical improvement, work that eventually led to international clinical trials targeting B cells in this disease. Dr. Stone is the Founding Executive Chairman of The IgG4ward! Foundation (www.igg4ward.org), an international advocacy group for people living with that disease.
Dr. Stone organized an international group of sub-specialty experts to create the Glucocorticoid Toxicity Index (GTI). This clinical outcome assessment (COA) has been employed in clinical trials and studies in 35 indications to date and led to the creation of a suite of COAs designed to assess glucocorticoid toxicity.
Dr. Stone has also written and edited a textbook of his own conception entitled A Clinician’s Pearls & Myths in Rheumatology (Springer). Two editions of this book have been published, most recently in 2023.
Education & Training
- Fellowship: UC San Francisco, Rheumatology, 1997
- Residency: Johns Hopkins Hospital***, Medicine, 1993
- Internship: Johns Hopkins Hospital***, Medicine, 1991
- Medical Education: Harvard Medical School, 1990
Board Certifications
- Internal Medicine, American Board of Internal Medicine
- Rheumatology, American Board of Internal Medicine
Languages Spoken
- Spanish
- German
- English
Age Group Treated
- Adults
Patient Feedback
4.921569 average rating from 102 reviews
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Dr. Stone and his staff are world class. The entire experience was a privilege to be able to be cared for by such an esteemed learned dr. His staff is excellent, the care is world class. I feel very lucky to be under his and his staff's care
2026-08-03
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Dr. Stone is superb! I would highly recommend him to family and friends.
2026-08-03
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My experience with Dr.Stone has been life changing.....all for the good. I'm so fortunate to have him as my physician.
2026-08-02
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Dr. Stone is an engaging and engaged physician. He has a good sense of humor and he asks good questions. I liked him a lot.
2026-07-20
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I truly appreciate the time energy and empathy of Dr. Stone.
2026-07-16
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I find Dr John Stone to be extremely knowledgeable, professional, and caring, and I appreciate his follow up to ensure I get the care and medications that I need
2026-07-15
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Dr. Stone and his entire office are wonderful. He has helped my husband tremendously over the last few years. We are out-of-state patients that travel specifically to Mass General to see him. And I can't say enough kind words about how compassionate, intelligent, and caring that he is and his office is. He literally saved my spouse's life a few years ago. So I'm very grateful to him and I will always be. Thank you.
2026-06-24
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I feel very fortunate to be under his care.
2026-06-23
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I have a rare manifestation of a rare disease, of which Dr. John Stone is the leading expert in the world. He is also such a brilliant and compassionate man. I feel such a sense of comfort knowing that if I need anything -I can contact him to help me navigate through this journey. Knowing this improves my mental health and thereby quality of daily life. He is the Best of the Best (: You should clone him.
2026-06-17
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I flew from out of state to see my doctor. He is such a great practitioner.
2026-05-24
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Dr. Stone is an excellent physician. First saw him in 2013 when I was very ill. He has given me years of a good quality of life. Now treats my wife too. We are fortunate to have him as a physician. Very smart and personable! Excellent!
2026-05-24
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Dr. Stone is the absolute best: knowledgable, with high level of focus on patient needs. Always treated in a compassionate and personable manner. Always worth the long train trip to MGH!
2026-05-23
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Dr Stone is probably the best physician I ever met. He is kind, humble, caring and professional.
2026-05-18
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Great specialist physician with compassion and great knowleadge.
2026-05-18
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Great experience, great doctor, great service, very attentive, very knowledgeable, explained everything wonderfully to me and what the results might be from the tests I will be taking in the future. Totally 100% satisfied with everything. Absolutely the best.
2026-05-14
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Dr Stone is exceptional in his knowledge as well as his interaction with patients
2026-05-11
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He listens and makes sure all my questions are answered
2026-05-04
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Dr. Stone is a prince and a great doctor. He has helped me immeasurably with my IgG4 disease. I have complete and total confidence in him.
2026-05-03
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Dr. Stone is a very caring and thoughtful doctor. He listened to all of my concerns and then talk to me about next steps.
2026-05-03
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He had some news that was not easy to deliver and did it with compassion. Although I have never met him, he put us at ease and was very receptive to questions
2026-04-29
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He's great!
2026-04-28
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Dr Stone is best doctor in MGH period !
2026-04-26
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I'm very grateful with Dr. Stone for taking the time to see me.
2026-04-19
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My only criticism of the provider is that there was no mention or justification for some of the blood tests that were ordered. Other than that, he was excellent.
2026-04-19
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Dr. John Stone and his staff are extremely helpful. I drive 6 hours to get care because of the high quality specialty care. I think Dr. Stone is amazing and inspires our family. He has given myself and our family a second chance at a quality life treating my IgG4-RD.
2026-04-18
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Dr Stone is a superb diagnostician and provider. [redacted]
2026-04-13
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I think it's important to know that John Sun's bedside manner is incredible. And yeah, he always talks to me in a way that I understand. And I certainly appreciate his expertise and advice. Yeah, I would highly recommend him.
2026-03-20
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From the beginning of my experience of meeting Dr. Stone, it was helpful, in fact helped my treatment immensely, and I'm very appreciative and I've always had a consistently good relationship.
2026-03-12
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He is a great doctor, great with the patient
2026-02-25
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Dr. Stone is the world-wide expert in his field regarding IgG4 RD. This expertise has my situation under control, which had minimized my symptoms.
2026-02-23
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Beyond excellent care from Dr. Stone.
2026-01-26
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Excellent knowledge of my issue
2026-01-18
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Dr. Stone is a friendly and caring doctor who was able to get my Pseudogout under control. He is very pleasant to deal with.
2026-01-14
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Dr Stone is always professional with a genuine manner. From the first visit I had with him I knew I was in competent hands
2025-12-22
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I travel from Florida to see Dr. Stone. He always explains everything clearly and makes me feel comfortable and I am so much calmer when I leave the office then when I arrived.
2025-12-21
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Excellent care. I have nothing else to say.
2025-12-17
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Dr. Stone is a Wonderfull person and great DR.
2025-12-14
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I would rate my experience with Dr. Stone as excellent.
2025-12-11
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I feel very fortunate to see Dr. Stone. He provides exceptional care, expertly addresses all aspects of my very rare condition, explains everything thoroughly, and gives me very clear instructions. Dr. Stone's care and recommendations have vastly improved my overall health and quality of life, and his obvious concern for my general well-being is very helpful and comforting.
2025-12-11
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Dr Stone was excellent. He spent a lot of time with me, listened intently to me, and explained everything to me in layman's term. By far, my experience with Dr Stone was the best I have ever had with a doctor.
2025-12-09
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I would highly recommend Dr. Stone to anybody. He's done a lot for me and I'm honored that I got to work with him and study.
2025-12-11
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Absolutely wonderful physician and human being.
2025-12-07
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Dr. Stone is great. He is a terrific listener, is very responsive and always gives good advice.
2025-12-03
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I feel very fortunate that he is my consultant physician. He is professional and knowledgeable, a good listener, kind and considerate.
2025-12-03
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Consistency - My experience with the department has always been thorough, kind, and efficient
2025-12-01
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Dr Stone immediately suspected the solution to a chronic and very painful problem that was misdiagnosed by many other providers most of my life. He focused in on the problem in a skilled and caring way with an immediate diagnostic plan . Dr Stone made me feel comfortable and relaxed, even partway through my first visit I felt like I had known him for years. I can't say enough positive things about Dr Stone, he has changed my life and I feel privileged to have been treated by him!
2025-12-03
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Dr. Stone is the world expert on the particular ailment which I possess. I saw him promptly. He was well informed for my particular case. He explained the details very thoroughly. He came up with a novel and useful treatment plan. I am always satisfied with his manner and kindliness and solicitous attitude as well as his expertise.
2025-11-13
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Dr. Stone was over the top competent, understanding, knew and followed my medical record very deeply, gave me very understandable advice. I had flown in from across the country in California to make this appointment. Everything went smoothly. Dr. Stone was extremely gracious, competent, helpful, and made my visit not just good for my mental health, not just good for my physical health, but also gave me hope for the future. [redacted]
2025-10-29
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Dr. Stone is the best doctor I have ever met. I am lucky to be his patient. He listens carefully and provides excellent advice.
2025-10-27
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Dr stone took the time to review my extensive medical history. Clearly stated his thoughts on ny conditions. He was warm friendly ans supportive
2025-10-25
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Excellent physician with superb knowledge of my medical condition. I could say he is the pioneer in this subject and I am fortunate to have him as my physician
2025-10-19
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Dr.Stone is very upbeat and positive. He is doing research which is very important for my care, and the care of thousands of people worldwide.
2025-10-19
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Dr.Stone is the best! I am very confident that he is giving the best care possible! He has been my doctor for 17 years!!! Wonderful man and doctor!?
2025-10-19
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superior provider.
2025-10-09
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Answered all questions .Always feel better when leave office because I'm in good hands
2025-10-08
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Dr Stone is a very good physician. He genuinely cares and takes his time. He is extremely well versed in his field and explains things well.
2025-10-06
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Blackstone is a very good provider that listens very attentively.
2025-10-02
Accepted Insurance
- Tufts Medicare Preferred
- Wellpoint
- Tufts Health Plan
- Senior Whole Health
- Multiplan
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- Beech Street
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