Mass General Brigham findings suggest new avenues for studying and treating inflammation in the future.
Authorship: In addition to Dou, Mass General Brigham authors include Yu Wang, Yaosi Liang, Marc Samuel Sherman, Yanxin Xu, Angelique Onorati, Kathleen E. Corey, Ana Maria Cabral Burkard, Chia-Kang Ho, Ulrike Rieprecht, Tara O'Brien, Murat Cetinbas, Ruslan I. Sadreyev, Robert E. Kingston, and Wolfram Goessling. Additional authors include Vinay V. Eapen, Athanasios Kournoutis, Xianting Li, Xiaoting Zhou, Kuo Du, Jing Xie, Hui Zhang, Raquel Maeso-Díaz, Xinyi Ma, Lu Wang, Jihe Liu, Corey Bretz, Aaron P. Havas, Zhuo Zhou, Shannan J. Ho Sui, Srinivas Vinod Saladi, Peter D. Adams, Anna Mae Diehl, Benjamin Alman, Zhenyu Yue, Xiao-Fan Wang, and Terje Johansen.
Disclosures: None.
Funding: This study was funded in part by the National Institutes of Health (R35GM137889, R01AG082785, R00AG053406, UG3CA268117, UH3CA268117, R21AG073894, R01CA244564, U54-AG075936, R01AG072520, R01NS060123, R01NS117590, UL1TR002541), the Glenn Foundation for Medical Research and AFAR Grant for Junior Faculty, the Hevolution/AFAR New Investigator award, the Research Council of Norway (TOPPFORSK grant 249884), the Harvard Stem Cell Institute, and the Glenn Foundation for Medical Research Postdoctoral Fellowships in Aging Research from American Federation for Aging Research (AFAR).
Paper cited: Wang, Y et al. “WSTF nuclear autophagy regulates chronic but not acute inflammation” Nature DOI: 10.1038/s41586-025-09234-1
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