Looking Ahead: Predictions for Neuroscience and Neurology in 2026

"Noninvasive brain imaging will cross a critical threshold: detecting subtle circuit-level changes before symptoms appear. This will enable proactive, precision-tailored interventions—adjusting neuromodulation, fine-tuning medications or introducing behavioral strategies at the earliest signs of deviation from healthy brain function."

Jodi Gilman, PhD
Investigator
Mass General Brigham

"AI will help us connect the dots between the body and the brain like never before. By integrating molecular and physiological data across organs, we’ll uncover new pathways driving brain disorders and identify novel targets to treat them—marking the start of truly integrated mind-body therapeutics."

Michael Wheeler, PhD
Investigator
Mass General Brigham

"Human cellular models will become the backbone of precision neurology. Advances now allow us to study how genetic background influences disease and to measure therapeutic response in human-relevant systems, fundamentally transforming how we assess efficacy, stratify patients, and reduce risks in the clinical translation of new therapeutics."

Tracy Young Pearse, PhD
Investigator
Mass General Brigham

“By 2026, neurorecovery after spinal cord injury is expected to reach a turning point as neural interfaces and closed-loop neuromodulation deliver durable, functionally meaningful outcomes. Building on breakthroughs like digital neural bridges restoring movement and non-invasive stimulation improving limb function, the next frontier is integrated, adaptive neuromodulation—combining electrical stimulation, chemical conditioning, and brain–computer interfaces with targeted rehabilitation. This shift from isolated experiments to standardized protocols reframes paralysis as a modifiable network disorder, paving the way for scalable, precision-driven neurorehabilitation.”

Randy Trumbower, PT, PhD
Investigator
Spaulding Rehab