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Ten Projects Advance at 4th Annual MESH Innovation Teams’ ‘Problem Day’

5 minute read
Researcher looks at a 3D rendering on the computer while adjusting a prototype

Top finalists to enter year-long program guiding their innovations, aimed at enhancing patient care

It’s surely a misnomer because “Problem Day” is no problem, at least for the 10 teams (13 participants) that earlier this month succeeded in the annual competition to learn from the expertise of a multi-disciplinary team of scientists, engineers, and clinicians eager to help them launch their great idea for improving health care, medicine, or technology.

The year-long acceleration program is run by the Medically Engineered Solutions in Healthcare (MESH) Incubator, Mass General Brigham’s in-house acceleration and entrepreneurship center led by Marc Succi, MD, who is the founder and executive director, as well as strategic innovation leader for Mass General Brigham Innovation. Specifically, the MESH Innovation Teams’ division, including Managing Director Peter Choi and team members Marin Langlieb, Chris Bak, Judah Soray, and Anne Philip, leverages biodesign principles to translate scientific discovery to commercial viability.

The program allows Mass General Brigham investigators to pitch their proposed innovation projects on "Problem Day," when they explain a problem they’ve encountered in health care and explain how they could turn it around with their proposed project.

Of the 10 projects initially selected, less than half will go on to become finalists and enter the intensive year-long program of targeted coaching from the MESH Innovation teams board. They receive guidance and first-hand experience from Mass General Brigham innovators and others in further prototyping their innovations, assessing the market opportunity, protecting their intellectual property, and planning a business that will ultimately better patient care. Finalists gain exposure to generating health care innovations and creating companies in the complex medical environment with access to Harvard physicians, residents, faculty, experienced entrepreneurs, and venture capital networking.

MESH Innovation teams, along with members from Mass General Brigham Innovation, hold structured focused workshops throughout the year to aid in the process. MESH Core serves as the cornerstone bootcamp as the project teams get underway.

The ultimate goal is patenting innovations and/or forming start-up companies. To date, Innovation teams have helped form several companies, including one acquisition and >20x follow-on funding, as well as produced numerous intellectual property disclosures or patents.

This year, more than 20 projects across Mass General Brigham and Harvard were considered, the 13 were selected and of the 13; about 4 to 6 projects will advance to the finalist stage.

Seed or beginning funding is available to the investigators, which is partly from institutional funds.

Projects and investigators

Augmented reality-guided breast reconstruction surgery 

Jayender Jagadeesan, PhD

A novel way of improving breast reconstruction to ensure symmetry between the two breasts (Brigham and Women’s Hospital)


Stefan Lukianov, AM; Herriet Hsieh; Shreya Sangam, PhD; Julia Olsen

A digital health care application for warfarin management that links patient self-care to clinical support, helping patients to better manage their disease (Harvard)

A compact linear scanning X-ray system for intra-operative spinal surgery guidance 

Kai Yang, PhD, DABR

A compact linear scanning X-ray system that will revolutionize surgery guidance and make spinal surgery safer (Massachusetts General Hospital)


Randy Bak, MD, JD

A platform that provides a single clinical workflow experience across all digital therapeutics, with back-end sign-on, ordering and team care services, all within the EMR experience, paid for by the digital therapeutics company, with provision of the digital therapeutic software-as-a-medical device under the physician’s dispensing privilege (Newton-Wellesley Hospital)

Drug dilution device 

Taylor Purvis, MD

A device that automatically calculates and performs medication dilutions, preventing errors and saving clinicians’ valuable time (Massachusetts General Hospital)


Soheil Ashkani-Esfahani, MD; Kelsey Detels, MS; and FARIL-SORG Collaborative Research Group

An AI-based, decision support tool that provides a smarter way of diagnosing and predicting orthopedic injuries (Massachusetts General Hospital)

Medical cast cutting device 

Steven Criss

A quiet, calm, low-cost alternative to the standard cast saw, providing a more comfortable experience for patients (Harvard)

AI model for non-invasive detection and monitoring of anemia 

Ritchie Verma, MD; Marko Velimirovic, MD, MMSc

A smartphone application that can diagnose and accurately monitor anemia over time by harnessing the power of artificial intelligence and a standard cell phone camera (Massachusetts General Hospital)

Intra-articular drug-delivery platform 

Nicole Beck, DMD, MBA; Briana Burris, DDS; Joseph P. McCain, DDS, FACS

Innovating drug-delivery modalities in orthopedics via technology that allows for controlled delivery of therapeutics into a joint (Massachusetts General Hospital)

Democratizing proton therapy 

Thomas Bortfeld, PhD; Susu Yan, PhD

A cost-effective solution to proton therapy that will enable more hospitals to offer this life-saving treatment (Massachusetts General Hospital)


For more information, contact Marc Succi.