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Creating solutions to health care’s unmet needs with emerging digital and AI technologies

Founded in 2020, with a $30 million commitment, the Artificial Intelligence and Digital Innovation Fund (AIDIF) invests in venture stage companies whose offerings further Mass General Brigham’s strategic initiatives, with a keen eye on:

  • Quality patient care
  • Equity
  • Cost reductions
  • Clinician well-being

As a companion to Mass General Brigham Ventures, which focuses on accelerating breakthroughs arising from its vast internal research, the Artificial Intelligence and Digital Innovation Fund concentrates on commercial stage digital health and AI-based, externally developed digital solutions to address unmet patient needs. To date, the fund has invested in three companies.

Because digital solutions to patient care require active testing, adaptation, and roll-out across clinical environments prior to widespread use, co-development relies on health systems, such as Mass General Brigham, that can help perfect these products and define how to integrate applications into clinical workflows, thereby creating reference models for other health systems. 

Improving patient care

Always on the cutting edge of care, Mass General Brigham is committed to substantially increasing the use of technology, data, and digital capabilities in the delivery and management of patient care. The system works tirelessly to increase digital innovation in every phase of care and every element of its operation. To this end, the system targets use collection and analysis of large data sets to implement break-through digital solutions. 

The first fund of this type at Mass General Brigham, AIDIF works closely with the health system’s clinical, operations, research and digital leadership and Innovation’s Business Development and Licensing team to identify key areas for investment and potential co-development opportunities. 

The Fund supports not only new business ventures in digital companies already partnering with Mass General Brigham but also co-development with industry, and execution of digital-based care delivery initiatives. AIDIF remains committed to advancing digital health solutions to market and accessing external collaborators and new technology. 


AIDIF brings together both venture investing and business development expertise that can add significant value to a portfolio company beyond just capital. For investment prospects that meet initial investment criteria, our team helps identify and introduce companies to relevant potential customers or co-development partners across the health system. 

These connections help portfolio companies expand within the Mass General Brigham system and beyond.

AIDIF provides financial return to support Mass General Brigham’s mission. It introduces innovative solutions to our health system (both provider and payer) and captures value created when the system adopts digital solutions.

The fund is slated to make one to three co-investments per year with digital health VC investors.

Our portfolio

The Artificial Intelligence and Digital Innovation Fund

  • Stage: Stage agnostic, but mainly Series A and Series B
  • Initial investment: $0.5–$1.5 million in a venture-led (priced) financing round
  • Strategic alignment
    • Value proposition advances Mass General Brigham’s key strategic initiative—Research and Innovation
    • Externally developed digital solutions embraced by the health system to address unmet medical needs
  • Product/market fit: Product offering meets a strategic stakeholder need with a contract under negotiation or signed by the time of investment

Who we are

AIDIF investment team

AIDIF business development team

AIDIF governance

The AIDIF governance structure is comprised of the investment committee and the board of managers.  

The AIDIF investment committee reviews AIDIF prospective investments and ensures they meet a threshold for venture capital return potential.  

The board of managers is comprised of senior leadership at MGB and ensures AIDIF investments align with the health system’s strategic objectives.